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Wellness Applications

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The insurgence of sophisticated wellness consumer demands for products and supplements enriched with herbal products as an initiative to obtain specific health benefits or prevent an illness has fuelled innovations towards the development of wellness products [1,2]. Dietary supplements can be used to fill in the nutritional gaps in diet, supporting overall and specific wellness goals, and providing alternative therapeutic options. Exosomes, which exist in plant and animal cells, play important roles in cell communication and nutrient delivery [3]. They are explored as potent therapeutic carriers due to their high stability, low immunogenicity, superior bioavailability, and the ability to increase their capacity to cross biological barriers, thus improving the biological effects of delivered molecules [4]. Their abundance of nutritional compounds, especially plant-derived exosomes-like nanoparticles (PDENs), which possesses high antioxidant and high anti-inflammatory properties, make the possibility of their incorporation in wellness applications limitless [5,6].

References

  1. Okareh, O. T., Oyelakin, T. M., & Ariyo, O. (2018). Phytochemical Properties and Heavy Metal Contents of Commonly Consumed Alcoholic Beverages Flavouredwith Herbal Extract in Nigeria. Beverages, 4(3), 60. https://www.mdpi.com/2306-5710/4/3/60#B1-beverages-04-00060

  2. Chavda, V. P., Patel, A. B., Vihol, D., Vaghasiya, D. D., Ahmed, K. M. S. B., Trivedi, K. U., & Dave, D. J. (2022). Herbal Remedies, Nutraceuticals, and Dietary Supplements for COVID-19 Management: An Update. Clinical Complementary Medicine and Pharmacology, 100021.https://www.sciencedirect.com/science/article/pii/S2772371222000031

  3. Akuma, P., Okagu, O. D., & Udenigwe, C. C. (2019). Naturally occurring exosome vesicles as potential delivery vehicle for bioactive compounds. Frontiers in Sustainable Food Systems, 3, 23. https://www.frontiersin.org/articles/10.3389/fsufs.2019.00023/full

  4. García-Martínez, J., Pérez-Castillo, Í. M., Salto, R., López-Pedrosa, J. M., Rueda, R., & Girón, M. D. (2022). Beneficial Effects of Bovine Milk Exosomes in Metabolic Interorgan Cross-Talk. Nutrients, 14(7), 1442. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003525/

  5. You, J. Y., Kang, S. J., & Rhee, W. J. (2021). Isolation of cabbage exosome-like nanovesicles and investigation of their biological activities in human cells. Bioactive materials, 6(12), 4321-4332. https://www.sciencedirect.com/science/article/pii/S2452199X21001924

  6. Alfieri, M., Leone, A., & Ambrosone, A. (2021). Plant-derived nano and microvesicles for human health and therapeutic potential in nanomedicine. Pharmaceutics, 13(4), 498. https://www.mdpi.com/1999-4923/13/4/498

Resource Centre

Plant-derived nano and microvesicles for human health and therapeutic potential in nanomedicine

Alfieri, M., Leone, A., & Ambrosone, A. (2021)

Naturally occurring exosome vesicles as potential delivery vehicle for bioactive compounds

Akuma, P., Okagu, O. D., & Udenigwe, C. C. (2019)

Plant-derived exosome-like nanoparticles and their therapeutic activities

Kim, J., Li, S., Zhang, S., & Wang, J. (2022)

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