top of page

Cosmeceutical Applications

Cosmeceutical.png

Skin serves as human body's largest protective barrier, and people have strived to improve the quality of their skin in improving their self-esteem of their social lives [1].  Skin aging associated with intrinsic (genetics) and extrinsic (UV exposure, air pollution, food, and mental stress) factors have led constant search of new skin therapy for skin regeneration and repair [2]. Exosomes are nano-sized vesicles secreted by most types of cells to communicate with each other. They can circulate through bodily fluids and transfer information not only to local cells but also to distance cells. Recent studies have shown exosomes to be a beneficial alternative for skin regenerative treatments as they offer the ability to repair and regenerate skin tissue [1,3]. Their exposure to the rat skin model can induce collagen production and vascularization, enhancing the wound healing process. Apart from that, exosomes can modulate the inflammation by reducing pro-inflammatory cytokines improving pathological symptoms in atopic dermatitis (AD) (eczema) skin lesions [4].

References

  1. Yang, G. H., Lee, Y. B., Kang, D., Choi, E., Nam, Y., Lee, K. H., ... & Jeon, H. (2021). Overcome the barriers of the skin: exosome therapy. Biomaterials Research, 25(1), 1-13.https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-021-00224-8

  2. Han, G., Kim, H., Kim, D. E., Ahn, Y., Kim, J., Jang, Y. J., ... & Kim, S. H. (2022). The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells. Pharmaceutics, 14(2), 307.https://www.mdpi.com/1999-4923/14/2/307

  3. Xiong, M., Zhang, Q., Hu, W., Zhao, C., Lv, W., Yi, Y., ... & Wu, Y. (2021). The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics. Pharmacological Research, 166, 105490.https://www.sciencedirect.com/science/article/pii/S1043661821000748

  4. Xiong, M., Zhang, Q., Hu, W., Zhao, C., Lv, W., Yi, Y., ... & Wu, Y. (2021). The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics. Pharmacological Research, 166, 105490.https://www.sciencedirect.com/science/article/pii/S1043661821000748#bib66

Image credits

•Yang, G. H., Lee, Y. B., Kang, D., Choi, E., Nam, Y., Lee, K. H., ... & Jeon, H. (2021). Overcome the barriers of the skin: exosome therapy. Biomaterials Research, 25(1), 22. https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-021-00224-8#Fig6
•Miller, J. D., Salloum, M., Button, A., Giovinco, N. A., & Armstrong, D. G. (2014). How can I maintain my patient with diabetes and history of foot ulcer in remission?. The international journal of lower extremity wounds, 13(4), 371-377. https://journals.sagepub.com/doi/abs/10.1177/1534734614545874?journalCode=ijla 

•Image by <a href="https://www.freepik.com/free-photo/beauty-portrait-feminine-young-woman-looking-away-touching-her-nude-shoulder-isolated-white_6514195.htm#query=healthy%20skin&position=22&from_view=search&track=sph">Image by drobotdean</a> on Freepik​

•Image by <a href="https://www.freepik.com/free-photo/woman-suffering-from rash_29961593.htm#query=eczema&position=16&from_view=search&track=sph">Freepik</a>

Resource Centre

Overcome the barriers of the skin: exosome therapy

Yang, G. H., Lee, Y. B., Kang, D., Choi, E., Nam, Y., Lee, K. H., ... & Jeon, H. (2021)

Exosome loaded alginate hydrogel promotes tissue regeneration in full‐thickness skin wounds: An in vivo study

Shafei, S., Khanmohammadi, M., Heidari, R., Ghanbari, H., Taghdiri Nooshabadi, V., Farzamfar, S., ... & Tavoosidana, G. (2020)

Apple Derived Exosomes Improve Collagen Type I Production and Decrease MMPs during Aging of the Skin through Downregulation of the NF-κB Pathway as Mode of Action

Trentini, M., Zanolla, I., Zanotti, F., Tiengo, E., Licastro, D., Dal Monego, S., ... & Zavan, B. (2022)

bottom of page